A-Methylacyl-CoA Racemase (AMACR) and Prostate-Cancer Risk: A Meta-Analysis of 4,385 Participants

A-Methylacyl-CoA Racemase (AMACR) and Prostate-Cancer Risk: A Meta-Analysis of 4,385 Participants

BACKGROUND Alpha-methylacyl-CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme that is overexpressed in prostate cancer. The aim of this study was to confirm and expand the findings that the PCa risk increased in men associated with AMACR expression across various geographic regions. METHODS A systematic search of databases was carried out and other relevant articles were also ide...

Association of Alpha-Methylacyl-CoA Racemase Gene Polymorphisms with Susceptibility to Prostate Cancer: a Meta-Analysis

Prostate cancer (PCa) is one of the most common malignancies in men with approximately 0.9 million newly diagnosed cases and 0.26 million deaths in 2008 worldwide (Jemal et al., 2011). Until now, the exact carcinogenic mechanism of prostate cancer has remained unclear (Mahmoud et al., 2014). It is widely accepted that carcinogenesis of prostate cancer is affected by genetic susceptibility and e...

Award Number : TITLE : Dietary Influences on Alpha - Methylacyl - CoA Racemase ( AMACR ) Expression in the Prostate

Humoral Immune Response to -Methylacyl-CoA Racemase and Prostate Cancer

Background: Although prostate-specific antigen (PSA) is a prototypic biomarker for prostate cancer, it has poor specificity. Expression of -methylacyl-CoA racemase (AMACR), which is involved in the conversion of Rstereoisomers of branched-chain fatty acids to S-stereoisomers, has been shown to be specifically increased in prostate cancer epithelia. However, attempts to detect AMACR in circulati...

High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S).

α-methylacyl coenzyme A racemase (AMACR) is a metabolic enzyme whose overexpression has been shown to be a diagnostic indicator of prostatic adenocarcinoma and other solid tumors. Here, we confirm that attenuation of AMACR expression diminishes the growth of prostate cancer cell lines by using stably expressed short-hairpin RNA constructs. This observation strongly suggests that the AMACR enzym...